Angiotensin II.

Angiotensin II (ANGII) is a peptide that increases blood pressure and is part of the renin-angiotensin-aldosterone system (RAAS). It has recently been approved as a vasopressor drug for the treatment of vasodilatory hypotension and shock in the ICU. The ATHOS-3 trial demonstrated that ANGII was effective in increasing mean arterial pressure and achieving target blood pressure in patients with catecholamine-refractory vasodilatory shock. Subgroup analyses showed that ANGII was particularly beneficial for patients on renal replacement therapy and those with elevated plasma renin concentration. Further studies are needed to determine the optimal timing, patient selection, and duration of ANGII therapy, as well as its use in combination with other agents. [Extracted from the article]