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A model for N-to-C direction in prebiotic peptide synthesis.
- Source :
-
Chemical Communications . 3/11/2024, Vol. 60 Issue 20, p2748-2751. 4p. - Publication Year :
- 2024
-
Abstract
- Drawing inspiration from the initiating amino acid modification in biosynthetic peptides, we have successfully demonstrated a biomimetic mechanism for N-to-C terminal extension in prebiotic peptide synthesis. This achievement was accomplished by using acetylated amino acid amides as the N-terminal substrate for peptide synthesis and amino acid amides as the C-terminal extension, with the reaction carried out in a dry-wet cycle at 80 °C without requiring any activators. This provides a plausible pathway for the formation of prebiotic peptides. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PEPTIDE synthesis
*AMINO acid amides
*AMINO acid synthesis
*FRUCTOOLIGOSACCHARIDES
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 60
- Issue :
- 20
- Database :
- Academic Search Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 175850045
- Full Text :
- https://doi.org/10.1039/d3cc06101a