慢性牙周炎伴咬合创伤患者龈沟液 Sclerostin、SLIT3 与牙周临床指标 和 RANKL-OPG 系统的相关性研究.

Objective: To investigate the correlation of sclerostin and nerve axon guidance factor 3（SLIT3） in gingival crevicular fluid with periodontal clinical indicators and nuclear factor-κb receptor activator ligand（RANKL)-osteoprotegerin（OPG） system in patients with chronic periodontitis and occlusal trauma. Methods: 123 patients with chronic periodontitis and occlusal trauma（trauma group） and 101 patients with chronic periodontitis without occlusal trauma（control group） who were admitted to our hospital from January 2021 to January 2023 were selected. Before treatment, the levels of Sclerostin, SLIT3, RANKL and OPG in gingival crevicular fluid were detected, the ratio of RANKL/OPG was calculated, and the clinical periodontal indexes such as bleeding index（SBI), plaque index（PLI), probing depth（PD） and attachment loss（AL） were evaluated. The correlation between Sclerostin, SLIT3 and periodontal clinical indicators, RANKL, OPG, RANKL/OPG was analyzed. Results: The levels of Sclerostin, SLIT3, RANKL, RANKL/OPG, PLI, SBI, AL and PD in gingival crevicular fluid in trauma group before treatment were higher than those in control group（P＜0.05), and OPG was lower than that in control group（P＜0.05). Sclerostin and SLIT3 in gingival crevicular fluid in trauma group were positively correlated with PLI,SBI, AL, PD, RANKL and RANKL/OPG ratio before treatment（P＜0.05), and negatively correlated with OPG（P＜0.05). Conclusion: The levels of Sclerostin and SLIT3 in gingival crevicular fluid of patients with chronic periodontitis and occlusal trauma are significantly increase, which is relate to the abnormal periodontal clinical indicators and the increase of RANKL/OPG. [ABSTRACT FROM AUTHOR]