重组牛碱性成纤维细胞生长因子外用凝胶联合耳内镜下软骨 - 软骨膜 修补术治疗鼓膜大穿孔的临床研究.

Objective: To investigate the clinical efficacy of recombinant bovine basic fibroblast growth factor（bFGF） external gel combined with ear endoscopic cartilage-perichondrium repair in the treatment of large tympanic membrane perforation. Methods: 120patients with large tympanic membrane perforation who were treated in the 981 Hospital of the Joint Logistics Support Force of the Chinese People’s Liberation Army from January 2021 to November 2022 were selected. Patients were divided into control group and study group according to the random number table method, 60 cases in each group. Control group received ear endoscopic cartilage-perichondrium repair, study group received recombinant bovine bFGF external gel combined with ear endoscopic cartilage-perichondrium repair. The healing condition, hearing condition [bone conduction hearing threshold, air conduction hearing threshold, air-bone gap（A-B gap）], inflammatory factors [tumor necrosis factor-α（TNF-α), interleukin-1β（IL-1β), interleukin-6（IL-6）] and complications were compared between two groups. Results: The number of healing cases in study group was higher than that in control group, and the average healing days were shorter than those in control group（P＜0.05). The bone conduction hearing threshold, air conduction hearing threshold and A-B gap decreased in two groups at 6 months after operation in study group were was lower than those of control group（P＜0.05). The levels of TNF-α, IL-1β and IL-6 in study group at 3 days after operation were was lower than those of control group（P＜0.05). The incidence of complications in study group was lower than that in control group（P＜0.05). Conclusion: Recombinant bovine bFGF external gel combine with ear endoscopic cartilage-perichondrium repair in the treatment of large tympanic membrane perforation, which can shorten the healing time of tympanic membrane, improve the hearing of patients, reduce the inflammatory reaction, and have good safety. [ABSTRACT FROM AUTHOR]