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Unlocking translational machinery for antitubercular drug development.
- Source :
-
Trends in Biochemical Sciences . Mar2024, Vol. 49 Issue 3, p195-198. 4p. - Publication Year :
- 2024
-
Abstract
- Targeting translational factor proteins (TFPs) presents significant promise for the development of innovative antitubercular drugs. Previous insights from antibiotic binding mechanisms and recently solved 3D crystal structures of Mycobacterium tuberculosis (Mtb) elongation factor thermo unstable–GDP (EF-Tu–GDP), elongation factor thermo stable–EF-Tu (EF-Ts–EF-Tu), and elongation factor G–GDP (EF-G–GDP) have opened up new avenues for the design and development of potent antituberculosis (anti-TB) therapies. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09680004
- Volume :
- 49
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Trends in Biochemical Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 175873525
- Full Text :
- https://doi.org/10.1016/j.tibs.2023.12.008