IFNγ: Priming for death.

TNF signaling does not result in cell death unless multiple inhibitory signals are overcome, which can be accomplished by simultaneous signaling through IFNγ. In this issue, Deng and colleagues (http://doi.org/10.1083/jcb.202305026) dissect the mechanisms by which IFNγ signaling combines with TNF tomediate cell death through caspase-8, discussed by James E. Vince. [ABSTRACT FROM AUTHOR]