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Systemic meta-analysis: apigenin's effects on lung inflammation and oxidative stress.
- Source :
-
Journal of Asthma . Apr2024, Vol. 61 Issue 4, p271-281. 11p. - Publication Year :
- 2024
-
Abstract
- This study aimed to investigate the potential anti-inflammatory and antioxidant effects of apigenin in rats with acute lung injury (ALI). We also examined changes in levels of inflammatory and antioxidant factors after apigenin treatment in a rat model of ALI. Methods: We searched several databases, including PubMed, Scopus, EMBASE, Web of Science, ProQuest, and GoogleScholar, to retrieve relevant articles for our systematic review and meta-analysis. Five studies with 226 rat models of ALI were included in this study. We investigated inflammatory factors and oxidative stress with the corresponding 95% confidence interval in three groups: 1. Group1 (control vs. ALI), 2. Group2 (ALI vs. apigenin10), and 3. Group3 (ALI vs. apigenin20). Estimating the correlation and 95% confidence intervals for the inflammatory agents and oxidative stress in the intervention group (ALI), compared with that in the control group, respectively (correlation: 0.194; 95% confidence intervals, 0.101–0.282, p value =.001, z-value= 4.08) and (correlation: 0.099; 95% confidence intervals, 0.016–0.182, p value =.020, z value= 2.325). Estimating the correlation and 95% confidence intervals for the inflammatory agents and oxidative stress in the intervention group (apigenin 10 mg/kg), compared with that in the control group (ALI), respectively (correlation: 0.476; 95% confidence intervals, 0.391–0.553, p value =.001, z-value= 9.678) and (correlation: 0.415; 95% confidence intervals, 0.313–0.508, p value=.001, z-value= 7.349). Apigenin may have potential anti-inflammatory and antioxidant effects in rat models of ALI. However, the efficacy of apigenin as a therapeutic strategy requires further investigation through prospective controlled randomized trials. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02770903
- Volume :
- 61
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Journal of Asthma
- Publication Type :
- Academic Journal
- Accession number :
- 175980175
- Full Text :
- https://doi.org/10.1080/02770903.2023.2272804