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Monoterpenoid indole alkaloids from Alstonia scholaris and their Toxoplasma gondii inhibitory activity.

Authors :
Wu, Pei-Qian
Liu, Zhen-Di
Ren, Yu-Hao
Zhou, Jun-Su
Liu, Qun-Fang
Wu, Yan
Zhang, Ji-Li
Zhou, Bin
Yue, Jian-Min
Source :
Phytochemistry. Apr2024, Vol. 220, pN.PAG-N.PAG. 1p.
Publication Year :
2024

Abstract

Nine previously unreported various types of monoterpenoid indole alkaloids, together with seven known analogues were isolated from the stem barks of Alstonia scholaris through a silica gel free methodology. The structures of 1 – 9 were elucidated by spectroscopic data analysis, electronic circular dichroism calculations, and single-crystal X-ray diffraction. Compound 1 is a modified echitamine-type alkaloid with a novel 6/5/5/7/6/6 hetero hexacyclic bridged ring system, and 8 and 9 exist as a zwitterion and trifluoroacetate salt, respectively. The anti- Toxoplasma activity of all isolates on infected Vero cells were evaluated, which revealed that compound 14 at 0.24 μM displayed potent activity. This study expanded the structural diversity of alkaloids of A. scholaris , and presented their potential application in anti- Toxoplasma drug development. Nine unreported various types of monoterpenoid indole alkaloids, together with seven known analogues were isolated from Alstonia scholaris through a silica gel free methodology. Several of isolates displayed potent activity against Toxoplasma gondii. [Display omitted] • Nine unreported alkaloids were isolated from Alstonia scholaris. • Alstoniaine A is a modified echitamine alkaloid with a unique hetero bridged ring. • Some compounds displayed potent anti- Toxoplasma gondii activity. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00319422
Volume :
220
Database :
Academic Search Index
Journal :
Phytochemistry
Publication Type :
Academic Journal
Accession number :
175984053
Full Text :
https://doi.org/10.1016/j.phytochem.2024.113993