A Facile Synthesis of 3′-Fluoro Hexitol Adenosine and Guanosine Phosphoramidites.

This article discusses the development of a synthesis method for 3'-fluoro hexitol nucleic acids (FHNA) adenosine and guanosine phosphoramidites. The authors explain that antisense technology, which involves using oligonucleotides to downregulate gene expression, has shown promise in drug discovery. They describe the synthesis of FHNA pyrimidine nucleoside phosphoramidites and their properties, as well as the challenges faced in synthesizing FHNA purine nucleosides. The authors present two alternate routes for the synthesis of FHNA purine nucleosides and detail the steps involved in the synthesis process. They conclude that their synthetic method will facilitate the use of FHNA nucleic acids in genetic medicine and diagnostic applications. [Extracted from the article]