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Long-term Survival in a Child with Malignant Insulinoma After Liver Transplantation.
- Source :
-
Journal of Clinical Research in Pediatric Endocrinology . Mar2024, Vol. 16 Issue 1, p106-110. 5p. - Publication Year :
- 2024
-
Abstract
- Insulinoma is one of the pancreatic neuroendocrine tumors (PanNET) and is exceptionally rare in children. The tumor leads to severe hypoglycemia caused by excessive insulin release. We report a pediatric patient with malignant insulinoma who underwent liver transplantation (LT) due to liver metastases of the insulinoma. A 13-year-old girl presented with symptoms of hypoglycemia due to hyperinsulinism. On computed tomography (CT), a polycystic lesion in the head of the pancreas and enlarged lymph nodes were revealed. A modified Whipple's operation was performed, and histological examination confirmed PanNET. CT also showed an enlarged liver with numerous metastases. Allogeneic LT was carried out successfully. Positron emission tomography-CT using 68Ga-DOTA-labeled somatostatin analogs (SSAs) at the age of 22 years confirmed complete metabolic remission. The patient currently remains under immunosuppressive and anti-proliferative treatment. Multiple surgical interventions, LT combined with SSAs, and immunosuppressive medication proved effective in this case of metastatic malignant insulinoma. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13085727
- Volume :
- 16
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Journal of Clinical Research in Pediatric Endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 176019176
- Full Text :
- https://doi.org/10.4274/jcrpe.galenos.2022.2022-3-5