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Punicalagin Opposes Gentamicin Nephrotoxicity in Rats: Role of Nrf2 and NF-κB Pathways.

Authors :
Fouad, Amr A.
Ali, Moataz Mohamedalhasan
Abdel-Hamid, Mostafa
Source :
Pharmacognosy Journal. Jan/Feb2024, Vol. 16 Issue 1, p126-130. 5p.
Publication Year :
2024

Abstract

Background: Oxidative stress, inflammation, and apoptosis are implicated in gentamicin (GEN)-induced nephrotoxicity. Punicalagin (PNG) possesses antioxidant, anti-inflammatory, and antiapoptotic effects. Objective: The aim of the present research was to investigate the possible defensive effect of PNG against nephrotoxicity caused by GEN in male Sprague-Dawley rats. Materials and Methods: GEN (80 mg/kg/day, i.p.) was administered for 8 days. Treatment with PNG (25 mg/kg/day, p.o.) for 10 days, began 2 days before GEN insult. Results: PNG significantly decreased serum creatinine, and malondialdehyde, tumor necrosis factor-a, interleukin-6, inducible nitric oxide synthase, nuclear factor-κB p65 (NF-κB p65), and cleaved caspase-3 activity in the kidneys of GEN-challenged rats. PNG also significantly increased renal catalase, reduced glutathione, and nuclear factor erythroid 2-related factor 2 (Nrf2) in rats received GEN. Additionally, PNG markedly attenuated the histopathological kidney tissue injury caused by GEN. Conclusion: PNG guarded against GEN-induced kidney damage in rats through its antioxidant, anti-inflammatory, and antiapoptotic effects, and by modulating the balance between Nrf2 and NF-κB pathways. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09753575
Volume :
16
Issue :
1
Database :
Academic Search Index
Journal :
Pharmacognosy Journal
Publication Type :
Academic Journal
Accession number :
176019219
Full Text :
https://doi.org/10.5530/pj.2024.16.17