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Adverse renal effects associated with cardiopulmonary bypass.
- Source :
-
Perfusion . Apr2024, Vol. 39 Issue 3, p452-468. 17p. - Publication Year :
- 2024
-
Abstract
- Cardiac surgery on cardiopulmonary bypass (CPB) is associated with postoperative renal dysfunction, one of the most common complications of this surgical cohort. Acute kidney injury (AKI) is associated with increased short-term morbidity and mortality and has been the focus of much research. There is increasing recognition of the role of AKI as the key pathophysiological state leading to the disease entities acute and chronic kidney disease (AKD and CKD). In this narrative review, we will consider the epidemiology of renal dysfunction after cardiac surgery on CPB and the clinical manifestations across the spectrum of disease. We will discuss the transition between different states of injury and dysfunction, and, importantly, the relevance to clinicians. The specific facets of kidney injury on extracorporeal circulation will be described and the current evidence evaluated for the use of perfusion-based techniques to reduce the incidence and mitigate the complications of renal dysfunction after cardiac surgery. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ULTRAFILTRATION
*THERAPEUTICS
*RENAL replacement therapy
*CREATININE
*HOMEOSTASIS
*SYSTEMIC inflammatory response syndrome
*NEPHROTOXICOLOGY
*CARDIOPULMONARY bypass
*ACUTE kidney failure
*SURGICAL complications
*DISEASES
*ARTERIAL pressure
*KIDNEY diseases
*ARTIFICIAL blood circulation
*PERFUSION
*CARDIAC surgery
*GLOMERULAR filtration rate
Subjects
Details
- Language :
- English
- ISSN :
- 02676591
- Volume :
- 39
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Perfusion
- Publication Type :
- Academic Journal
- Accession number :
- 176064966
- Full Text :
- https://doi.org/10.1177/02676591231157055