First electrochemical investigation and determination of non-steroidal anti-inflammatory drug etofenamate using disposable pencil graphite electrode with voltammetric techniques.

In this study, the electrochemical properties of etofenamate, an active ingredient belonging to the non-steroidal anti-inflammatory drug group, were investigated using cyclic voltammetry (CV) and square wave voltammetry (SW) techniques on a disposable pencil graphite electrode (PGE). With the CV technique, reversible voltammetric waves of around +0.470 V and irreversible voltammetric waves of around +1.02 V were produced on the PGE. An environmentally friendly, selective and highly sensitive SW voltammetric method was developed using disposable PGE. This voltammetric method gave very good analytical working range on PGE in PBS (pH = 3.0) medium at concentrations ranging from 0.017 μM to 0.306 μM. The LOD value of this analytical method in PBS (pH = 3.0) medium was calculated as 0.0011 μM (0.406 μg L−1). The developed voltammetric method was successfully applied to urine and drug samples. The results of the voltammetric method were compared with the results of the spectrophotometric method. The results were found to be compatible with each other. [Display omitted] • Pencil graphite electrode was employed for the first time for determination of Etofenamate. • Benefits of method: rapidity, simplicity, sensitivity and repeatability. • The procedure was successfully applied to determination of Etofenamate urine and drug samples. [ABSTRACT FROM AUTHOR]