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Exploring systemic inflammation in children with chronic kidney disease: correlates of interleukin 6.
- Source :
-
Pediatric Nephrology . May2024, Vol. 39 Issue 5, p1567-1576. 10p. - Publication Year :
- 2024
-
Abstract
- Background: Systemic inflammation (SI) is linked to chronic kidney disease (CKD) progression and multiple complications. Data regarding SI biomarkers in pediatric patients are scarce. This case–control and cross-sectional study investigates the correlation of neutrophil–lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), total iron binding capacity (TIBC) and serum albumin to serum interleukin-6 (IL-6). Methods: NLR and PLR were measured in 53 patients (median age: 12.9 years), including 17 on dialysis and 36 with a median glomerular filtration rate of 39 ml/min/1.73m2, and in 25 age and sex-matched healthy controls. Iron profile, serum albumin and IL-6 were measured in the patient group. IL-6 levels > 3rd quartile were classified as high. Results: Patients presented higher NLR and PLR and particularly those on dialysis (p < 0.001 and p = 0.001). We observed a significant correlation between natural logarithm (ln) of IL-6 (lnIL-6) and NLR (rs = 0.344, p = 0.014), serum albumin (rs = -0.350, p = 0.011) and TIBC (rs = -0.345, p = 0.012) after adjustment for CKD stage, while the correlation between lnIL-6 and PLR was not significant (rs = 0.206, p = 0.151). Combination of NLR, serum albumin and TIBC predicted high IL-6 (13 patients) with an AUC of 0.771 (95% CI 0.608–0.943). Pairing of NLR ≥ 1.7 and TIBC ≤ 300 μg/dL exhibited the highest sensitivity (76.9%), while incorporating serum albumin ≤ 3.8 g/dL along with them achieved the highest specificity (95%) for detecting high IL-6 levels. Conclusion: Both NLR and PLR levels increase in CKD, especially in patients on chronic dialysis. NLR, rather than PLR, along with TIBC and serum albumin, are associated with IL-6 in pediatric CKD. [ABSTRACT FROM AUTHOR]
- Subjects :
- *IRON analysis
*NEUTROPHIL lymphocyte ratio
*CROSS-sectional method
*STATISTICAL correlation
*IRON in the body
*RECEIVER operating characteristic curves
*SYSTEMIC inflammatory response syndrome
*DESCRIPTIVE statistics
*CHRONIC kidney failure
*PLATELET lymphocyte ratio
*LONGITUDINAL method
*CASE-control method
*RESEARCH
*INTERLEUKINS
*SERUM albumin
*DISEASE progression
*BIOMARKERS
*GLOMERULAR filtration rate
*SENSITIVITY & specificity (Statistics)
*CHILDREN
Subjects
Details
- Language :
- English
- ISSN :
- 0931041X
- Volume :
- 39
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Pediatric Nephrology
- Publication Type :
- Academic Journal
- Accession number :
- 176081526
- Full Text :
- https://doi.org/10.1007/s00467-023-06234-z