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Causal analysis between gastroesophageal reflux disease and chronic rhinosinusitis.
- Source :
-
European Archives of Oto-Rhino-Laryngology . Apr2024, Vol. 281 Issue 4, p1819-1825. 7p. - Publication Year :
- 2024
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Abstract
- Background: Gastroesophageal reflux disease (GERD) and chronic rhinosinusitis (CRS) have been shown to be potentially closely related, but the relationship between these conditions, particularly the possibility of a causal link, is not fully understood. This study used Mendelian randomization (MR) to assess the causal relationship between these two disorders. Methods: We extracted genome-wide association study data sets for GERD and CRS from publicly available gene summaries, and used MR to conduct a causal inference analysis. The main robustness test used in this study included MR-Egger regression, a leave-one-out sensitivity test, and multivariate MR (MVMR). Results: GERD increased the risk of developing CRS by 36%, based on the inverse-variance weighted method, a statistically significant association (odds ratio [OR] 1.360, 95% confidence interval [CI] 1.179–1.568, P < 0.001). Other MR assessment methods, such as weighted median, simple mode, and weighted mode, similarly observed a significant increase in the risk of CRS occurrence (OR 1.434, 95% CI 1.186–1.734, P < 0.001; OR 1.927, 95% CI 1.166–3.184, P = 0.013; and OR 1.910, 95% CI 1.222–2.983, P = 0.006, respectively). No significant bias was found in the heterogeneity or pleiotropy tests (P = 0.071 and P = 0.700, respectively). Even after excluding possible mediators using MVMR, GERD appeared to significantly increase the risk of developing CRS (OR 1.013, 95% CI 1.008–1.023, P = 0.002). Conclusions: This study provides new, significant evidence that GERD is genetically associated with a higher incidence rate of CRS. However, further research is needed to elucidate the potential underlying biological mechanisms of this relationship. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09374477
- Volume :
- 281
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- European Archives of Oto-Rhino-Laryngology
- Publication Type :
- Academic Journal
- Accession number :
- 176083125
- Full Text :
- https://doi.org/10.1007/s00405-023-08350-w