血清CC16、sRAGE水平与 ARDS患者疾病转归的 相关性及预测价值研究.

Objective To investigate the correlation between serum protein 16（CC16), soluble advanced glycation end product receptor (sRAGE) and the disease outcome in patients with acute respiratory distress syndrome（ARDS) and their predictive value. Methods A total of 127 ARDS patients admitted to the Second People′s Hospital of lingbao city from January 2021 to January 2023 were selected as the research objects, and the patients were divided into the mild group（39 cases), the moderate group（52 cases) and the severe group（36 cases) according to the severity of ARDS. The levels of serum CC16, sRAGE, oxygenation index（PaO2/FiO2), acute physiology and chronic health status Ⅱ（APACHEⅡ) scores and sequential organ failure assessment（SOFA) scores were compared between patients with different severity and patients with different disease outcomes, and the correlation between serum CC16, sRAGE levels and PaO2/FiO2, APACHEⅡ scores, SOFA scores and disease outcomes was analyzed. Logistic regression was used to analyze the risk factors of ARDS patients′ death, and ROC curve was used to analyze the predictive value of combined detection and each individual of serum CC16 and sRAGE levels for ARDS patients′ death. Results Comparison of serum CC16, sRAGE levels, and APACHEⅡ, SOFA scores of patients with different degrees of ARDS at admission: the mild group ＜ the moderate group ＜ the severe group, PaO2/FiO2 comparison: the mild group ＞ the moderate group＞ the severe group, the differences were all statistically significant（P＜0. 05); Serum CC16, sRAGE level, and APACHEⅡ, SOFA scores of the dead patients were higher than those of the surviving patients, and PaO2/FiO2 was lower than that of the surviving patients, and the differences were all statistically significant（P＜0. 05); Serum levels of CC16 and sRAGE were negatively correlated with PaO2/FiO2 on admission, and were positively correlatied with APACHEⅡ, SOFA scores, and disease outcome（P＜0. 05). Serum CC16 and sRAGE levels at admission were risk factors for mortality in ARDS patients. Moreover, the ROC area under the curve of combined detection of two index of the ARDS patients was greater than that of each individual index（P＜0. 05). Conclusion The expression of serum CC16 and sRAGE in ARDS patients is up-regulated, which is closely related to disease outcome, and can be used as an effective indicator for early clinical predictive to outcome. [ABSTRACT FROM AUTHOR]