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Immunoglobulin G4-related Disease: A Series of Four Cases.
- Source :
-
Journal of Clinical & Diagnostic Research . Mar2024, Vol. 18 Issue 3, p5-8. 4p. - Publication Year :
- 2024
-
Abstract
- Immunoglobulin G4-related Disease (IgG4-RD) is an immune-mediated fibroinflammatory disease that affects multiple organs, resulting in tumefactive lesions and/or organ dysfunction. This chronic, multiorgan inflammatory process is characterised by the infiltration of IgG4-positive plasma cells and has a variable clinical presentation depending on the organ involved. The present case series discusses four cases (two males and two females) of IgG4-RD involving different sites in patients presented to present Institution. The authors reviewed four cases of IgG4-RD, including clinical details, biochemical, radiological, and histopathological features. The case series includes IgG4-RD masquerading as meningioma, IgG4-related sclerosing cholangitis, IgG4-RD of the thyroid gland, and IgG4-RD of the lacrimal gland. Since IgG4-RD has non specific clinical features, histopathological analysis and immunohistochemistry play a pivotal role in diagnosis. Despite its diagnostic difficulties, earlier recognition is crucial to prevent significant morbidity and extensive fibrosis leading to organ failure. [ABSTRACT FROM AUTHOR]
- Subjects :
- *LACRIMAL apparatus
*SYMPTOMS
*INFLAMMATION
*THYROID gland
*PLASMA cells
*CHOLANGITIS
Subjects
Details
- Language :
- English
- ISSN :
- 0973709X
- Volume :
- 18
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Journal of Clinical & Diagnostic Research
- Publication Type :
- Academic Journal
- Accession number :
- 176113659
- Full Text :
- https://doi.org/10.7860/JCDR/2024/67738.19190