Practice Nurse Bite-Sized Learning: Understanding Familial Hypercholesterolemia.

The article focuses on familial hypercholesterolemia (FH), a genetic condition leading to high LDL cholesterol levels and significantly increased risk of premature heart disease, affecting approximately 220,000 people in the United Kingdom, yet less than 8% are currently identified. It discusses the genetic basis of FH involving LDL receptor genes, APOB gene, and PCSK9 gene, outlines detection methods including opportunistic, systematic, and cascade testing.