Back to Search
Start Over
Effects of Ecklonia stolonifera Extract on Metabolic Dysregulation in High-Fat Diet-Induced Obese Mice.
- Source :
-
Journal of Medicinal Food . Mar2024, Vol. 27 Issue 3, p242-249. 8p. - Publication Year :
- 2024
-
Abstract
- This study aimed to test the hypothesis that long-term and low-dose supplementation with an ethanol extract of Ecklonia stolonifera may confer protection against high-fat diet (HFD)-induced obesity in mice. Male C57BL/6J mice were divided into two groups, one of which was fed an HFD (40 kcal% fat) and the other an HFD+E. stolonifera (0.006%, w/w, ∼5 mg/kg body weight/day) for 16 weeks. E. stolonifera supplementation significantly reduced body weight from week 3 and until the end of the experiment. E. stolonifera-supplemented mice also exhibited lower fat mass (epididymal, perirenal, and mesenteric fat) and smaller adipocyte size than HFD control mice. The two groups displayed similar food intakes, but E. stolonifera markedly decreased lipogenesis and increased lipolysis and fatty acid oxidation in adipose tissue. Moreover, E. stolonifera significantly decreased plasma and hepatic lipid levels, hepatic lipid droplet accumulation, plasma aminotransferase levels, and liver weight by decreasing lipogenesis and increasing fatty acid oxidation. As E. stolonifera-supplemented mice showed improvements in hyperglycemia, insulin resistance, and inflammation, compared to control mice, it is possible that the beneficial effects of E. stolonifera on obesity might be associated with decreased inflammation and insulin resistance. Collectively, these results indicate that E. stolonifera could be used as a novel means of preventing and treating obesity and obesity-related metabolic disorders. [ABSTRACT FROM AUTHOR]
- Subjects :
- *OBESITY complications
*INFLAMMATION prevention
*HYPERGLYCEMIA prevention
*METABOLIC disorders
*OXIDATION-reduction reaction
*ANTI-inflammatory agents
*ADIPOSE tissues
*FOOD consumption
*ANTILIPEMIC agents
*FAT cells
*LIPIDS
*ALGAE
*DIETARY fats
*DESCRIPTIVE statistics
*HYPOGLYCEMIC agents
*MICE
*INSULIN resistance
*ANTIOBESITY agents
*ANIMAL experimentation
*TISSUE extracts
*COMPARATIVE studies
*FATTY acids
*LIVER
*DIETARY supplements
*OBESITY
*AMINOTRANSFERASES
*PHARMACODYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 1096620X
- Volume :
- 27
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Journal of Medicinal Food
- Publication Type :
- Academic Journal
- Accession number :
- 176118452
- Full Text :
- https://doi.org/10.1089/jmf.2023.K.0252