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Metallic radionuclide-labeled tetrameric 2,6-diisopropylphenyl azides for cancer treatment.
- Source :
-
Chemical Communications . 3/25/2024, Vol. 60 Issue 24, p3291-3294. 4p. - Publication Year :
- 2024
-
Abstract
- This study proposes a new method for radionuclide therapy that involves the use of oligomeric 2,6-diisopropylphenyl azides and a chelator to form stable complexes with metallic radionuclides. The technique works by taking advantage of the endogenous acrolein produced by cancer cells. The azides react with the acrolein to give a diazo derivative that immediately attaches to the nearest organelle, effectively anchoring the radionuclide within the tumor. Preliminary in vivo experiments were conducted on a human lung carcinoma xenograft model, demonstrating the feasibility of this approach for cancer treatment. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 60
- Issue :
- 24
- Database :
- Academic Search Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 176119455
- Full Text :
- https://doi.org/10.1039/d4cc00048j