Back to Search
Start Over
Skin healthcare protection with antioxidant and anti-melanogenesis activity of polysaccharide purification from Bletilla striata.
- Source :
-
International Journal of Biological Macromolecules . Mar2024:Part 2, Vol. 262, pN.PAG-N.PAG. 1p. - Publication Year :
- 2024
-
Abstract
- In this study, we investigated the structural characterization and biological activities of Bletilla striata polysaccharides (BSPs) for their role as antioxidants and anti-melanogenesis agents in skin healthcare protection. Three neutral polysaccharides (BSP-1, BSP-2, and BSP-3) with molecular weights of 269.121 kDa, 57.389 kDa, and 28.153 kDa were extracted and purified. Their structural characteristics were analyzed by ion chromatography, GC–MS, and 1D/2D NMR. The results showed that BSP-1, which constitutes the major part of BSPs, was composed of α-D-Glcp, β-D-Glcp, β-D-Manp, and 2- O -acetyl-β-D-Manp, with the branched-chain accompanied by β-D-Galp and α-D-Glcp. BSP-1, BSP-2, and BSP-3 can enhance the total antioxidant capacity of skin fibroblasts with non-toxicity. Meanwhile, BSP-1, BSP-2, and BSP-3 could significantly inhibit the proliferative activity of melanoma cells. Among them, BSP-1 and BSP-2 showed more significance in anti-melanogenesis, tyrosinase inhibition activity, and cell migration inhibition. BSPs have effective antioxidant capacity and anti-melanogenesis effects, which should be further emphasized and developed as skin protection components. [Display omitted] • Three antioxidant polysaccharides (BSP-1, BSP-2, and BSP-3) were isolated from Bletilla striata. • BSPs can enhance the intracellular T-AOC of skin fibroblasts with non-toxicity. • BSPs have antiproliferative effects on B16F10 cells. • BSP-2 and BSP-3 significantly inhibit melanogenesis, tyrosinase activity and cell migration of B16F10. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01418130
- Volume :
- 262
- Database :
- Academic Search Index
- Journal :
- International Journal of Biological Macromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 176151071
- Full Text :
- https://doi.org/10.1016/j.ijbiomac.2024.130016