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A Case of LGI1 Encephalitis Presenting with NORSE.
- Source :
-
Archives of Epilepsy . 2024, Vol. 30 Issue 1, p36-38. 3p. - Publication Year :
- 2024
-
Abstract
- New-onset refractory status epilepticus (NORSE) is a rare, life-threatening clinical presentation in patients without a known history of epileptic seizures. Autoimmune encephalitis is the most common cause identified in adults; however, in up to 50% of cases, no cause can be found. We present a case of a previously healthy 26-year-old male admitted to the intensive care medicine with NORSE, whose condition improved with the initiation of immunotherapy. Later, he was diagnosed with anti-leucine-rich glioma-inactivated 1 (anti-LGI1) antibody encephalitis. Despite prompt initiation of immunotherapy, cognitive function deterioration and resistant seizures persisted. NORSE is a critical condition that requires urgent treatment. In patients with a negative initial work-up, a preliminary diagnosis of autoimmune encephalitis should be considered. It is critical to begin immunotherapy before the autoimmune encephalitis panel results, as early treatment improves outcomes and long-term prognosis. [ABSTRACT FROM AUTHOR]
- Subjects :
- *BRAIN physiology
*STATUS epilepticus diagnosis
*STATUS epilepticus treatment
*LEUCINE metabolism
*PROTEIN metabolism
*COGNITION disorder risk factors
*AUTOIMMUNE disease treatment
*THERAPEUTIC use of immunoglobulins
*AUTOIMMUNE disease diagnosis
*RISK assessment
*HETEROCYCLIC compounds
*ADRENOCORTICAL hormones
*DIFFERENTIAL diagnosis
*IMMUNOTHERAPY
*RARE diseases
*ELECTROENCEPHALOGRAPHY
*IMMUNOGLOBULINS
*STATUS epilepticus
*TREATMENT effectiveness
*MAGNETIC resonance imaging
*ORAL drug administration
*RITUXIMAB
*NEUROLOGICAL disorders
*INTRAVENOUS therapy
*AUTOIMMUNE diseases
*SEIZURES (Medicine)
*INTENSIVE care units
*VALPROIC acid
*AMNESIA
*METHYLPREDNISOLONE
*COMORBIDITY
*DISEASE risk factors
*SYMPTOMS
Subjects
Details
- Language :
- English
- ISSN :
- 27920550
- Volume :
- 30
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Archives of Epilepsy
- Publication Type :
- Academic Journal
- Accession number :
- 176162688
- Full Text :
- https://doi.org/10.4274/ArchEpilepsy.2023.23093