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Boosting corrosion resistance and osteogenic activity of magnesium-based implants with metal ions chelated silk fibroin coating via binary solvent system.
- Source :
-
Chemical Engineering Journal . Apr2024, Vol. 485, pN.PAG-N.PAG. 1p. - Publication Year :
- 2024
-
Abstract
- [Display omitted] • An innovative method has been developed for creating metal ion-chelated silk fibroin coatings using a binary-solvent system. • Increased β -sheet content (45.4%) and crystallinity in silk fibroin result in enhanced corrosion resistance. • A universal mechanism for stepwise nucleation induced by binary solvent has been proposed. • The chelation of Ca2+ and Sr2+ into silk fibroin facilitates controlled release, thereby enhancing osteogenic activity. The development of biofunctional coating is vital for the clinical application of implants. A persistent challenge with magnesium alloys implants, which are inherently prone to rapid degradation, is the simultaneously enhancement of corrosion resistance and bioactivity. This study introduces a novel protein coating for magnesium alloys, incorporating calcium and strontium ions with silk fibroin. By utilizing the microcrystal nucleation facilitated by a binary solvent system, the β -sheet content is significantly increased to 45.4 % in silk fibroin. The increased β -sheet bolsters the "labyrinth effect" at the nanoscale, resulting in a substantial improvement in corrosion resistance. This is evidenced by a three-order-of-magnitude reduction in the corrosion current density (I corr) to 3.65 × 10−7 A cm−2, compared to that of the uncoated alloys. The meticulous doping of Ca2+ and Sr2+ ions ensures stable chelation with amorphous segments of silk fibroin. The controlled release activates the Wnt signaling pathway, boosting osteogenic activity. Such silk fibroin coating system, prepared through a straightforward method, enables a concurrent enhancement of both corrosion resistance and osteogenic potential in biomedical magnesium alloys. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13858947
- Volume :
- 485
- Database :
- Academic Search Index
- Journal :
- Chemical Engineering Journal
- Publication Type :
- Academic Journal
- Accession number :
- 176227589
- Full Text :
- https://doi.org/10.1016/j.cej.2024.149905