Back to Search Start Over

Long-term effects of chronic exposure to electronic cigarette aerosol on the cardiovascular and pulmonary system in mice: A comparative study to cigarette smoke.

Authors :
Dai, Yuxing
Yang, Wanchun
Song, Hongjia
He, Xiangjun
Guan, Ruoqing
Wu, Zehong
Jiang, Xingtao
Li, Min
Liu, Peiqing
Chen, Jianwen
Source :
Environment International. Mar2024, Vol. 185, pN.PAG-N.PAG. 1p.
Publication Year :
2024

Abstract

[Display omitted] Electronic cigarettes (e-cigarettes) have rapidly gained popularity as alternatives to traditional combustible cigarettes. However, their long-term health impact remains uncertain. This study aimed to investigate the effects of chronic exposure to e-cigarette aerosol (ECA) in mice compared to conventional cigarette smoke (CS) exposure. The mice were exposed to air (control), low, medium, or high doses of ECA, or a reference CS dose orally and nasally for eight months. Various cardiovascular and pulmonary assessments have been conducted to determine the biological and prosthetic effects. Histopathological analysis was used to determine structural changes in the heart and lungs. Biological markers associated with fibrosis, inflammation, and oxidative stress were investigated. Cardiac proteomic analysis was applied to reveal the shared and unique protein expression changes in ECA and CS groups, which related to processes such as immune activation, lipid metabolism, and intracellular transport. Overall, chronic exposure to ECA led to adverse cardiovascular and pulmonary effects in mice, although they were less pronounced than those of CS exposure. This study provides evidence that e-cigarettes may be less harmful than combustible cigarettes for the long-term health of the cardiovascular and respiratory systems in mice. However, further human studies are needed to clarify the long-term health risks associated with e-cigarette use. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
01604120
Volume :
185
Database :
Academic Search Index
Journal :
Environment International
Publication Type :
Academic Journal
Accession number :
176229226
Full Text :
https://doi.org/10.1016/j.envint.2024.108521