Recent Advances in Transition-Metal-Catalyzed Sonogashira Cross-Coupling Reactions of Alkyl Electrophiles.

This article provides an overview of recent advancements in transition-metal-catalyzed Sonogashira cross-coupling reactions of alkyl electrophiles. It discusses the challenges associated with coupling nonactivated alkyl electrophiles and highlights three catalytic systems that have been developed to address these challenges. The article also mentions the development of enantioselective Sonogashira reactions using copper catalysts with chiral ligands. The challenges and future directions in this field are also discussed. [Extracted from the article]