New, Old, and Shared Antibody Specificities in Autoimmune Diseases.

This document is a summary of a special issue on antibodies and autoantibodies in autoimmune diseases. The contributions in the issue cover various topics related to the role of antibodies in autoimmune diseases such as systemic sclerosis (SSc). The first two contributions focus on anti-CXCL4 antibodies in SSc patients, while the third contribution discusses strategies to reduce the immunogenicity of antibodies used in therapy. The fourth contribution explores the role of natural antibodies in mediating inflammation and autoimmune diseases. The fifth contribution examines the association between SSc-specific autoantibodies and microvascular abnormalities. The conclusion suggests further research on the topics discussed in the contributions, including the study of specific antibodies in other autoimmune diseases and the development of new therapeutic approaches. The authors declare no conflicts of interest. [Extracted from the article]