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Isolation of Lactobacillus acidophilus strain and its anti-obesity effect in a diet induced obese murine model.
- Source :
-
Letters in Applied Microbiology . Mar2024, Vol. 77 Issue 3, p1-7. 7p. - Publication Year :
- 2024
-
Abstract
- Intestinal microbiota is a potential determinant of obesity, with probiotic bile salt hydrolase (BSH) as one of the key mechanisms in the anti-obesity effects. In this study, we present a Lactobacillus acidophilus GOLDGUT-LA100 (LA100) with high BSH activity, good gastric acid and bile salt tolerance, and a potential anti-obesity effect. LA100's anti-obesity effects were evaluated in a high-fat diet-induced, obese mouse model. LA100 administration alleviates high-fat diet-induced pathophysiological symptoms, such as body weight gain, high serum glucose and cholesterol level, hepatic lipid accumulation, and adipose inflammation. These results demonstrate concrete anti-obesity benefit in animal models and show promising applications in future clinical studies. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02668254
- Volume :
- 77
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Letters in Applied Microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 176342084
- Full Text :
- https://doi.org/10.1093/lambio/ovae021