Inhibition of cancer cells by Quinoline-Based compounds: A review with mechanistic insights.

This comprehensive review delves into the intricate world of the Quinoline scaffold, unravelling its pivotal role as a molecular cornerstone in the relentless battle against cancer, poised to emerge as an indispensable pharmacophore in the forefront of cutting-edge drug development. [Display omitted] • Mechanisms of Quinoline Anticancer Action. • Therapeutic Promise & Implications. • Quinoline-Based Compounds Review. This article includes a thorough examination of the inhibitory potential of quinoline-based drugs on cancer cells, as well as an explanation of their modes of action. Quinoline derivatives, due to their various chemical structures and biological activity, have emerged as interesting candidates in the search for new anticancer drugs. The review paper delves into the numerous effects of quinoline-based chemicals in cancer progression, including apoptosis induction, cell cycle modification, and interference with tumor-growth signaling pathways. Mechanistic insights on quinoline derivative interactions with biological targets enlightens their therapeutic potential. However, obstacles such as poor bioavailability, possible off-target effects, and resistance mechanisms make it difficult to get these molecules from benchside to bedside. Addressing these difficulties might be critical for realizing the full therapeutic potential of quinoline-based drugs in cancer treatment. [ABSTRACT FROM AUTHOR]