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Gold nanoclusters – 2D MoS2 nano couple: An immunosensor for the fluorescence turn-on detection of heart failure Biomarker Brain Natriuretic Peptide (BNP).
- Source :
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Journal of Photochemistry & Photobiology A: Chemistry . Jul2024, Vol. 452, pN.PAG-N.PAG. 1p. - Publication Year :
- 2024
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Abstract
- Graphical representation of fluorescence turn-on detection of BNP antigen-by-BNP specific antibody tagged gold nanoclusters – MoS 2 nanosheet nano couple. [Display omitted] • An easy and prompt method for the detection of heart failure biomarker was achieved with gold nanocluster / 2D MoS 2 nanosheets. • A stable fluorescence turn - on response was observed with the probe in presence of BNP in physiologically significant serum concentration levels. • The development of the probe and detection of BNP antigen can be achieved within minutes without any high-end instruments. • The probe exhibited a low detection limit of 0.165 pg/mL. In the context of elevated morbidity and mortality risk of heart failure (HF), the establishment of prompt and sensitive diagnosis of HF is vital. A nanostructured fluorescence immuno sensing probe was constructed out of noble metal nanoclusters / two-dimensional transition metal dichalcogenide nano couple to target brain natriuretic peptide (BNP) antigen, a potential multi-utility heart failure biomarker. The green fluorescence of BNP-specific monoclonal antibody-conjugated gold nanoclusters was pre-quenched by a MoS 2 two-dimensional nanosheet, which is subsequently enhanced in the presence of BNP antigen via target-specific antigen–antibody interaction. The probe is free from interferences by other potentially interfering possible co-existing biomolecules and offers easy, low-cost linear detection of BNP in the concentration range 0 to 360.82 pg/mL. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10106030
- Volume :
- 452
- Database :
- Academic Search Index
- Journal :
- Journal of Photochemistry & Photobiology A: Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 176357607
- Full Text :
- https://doi.org/10.1016/j.jphotochem.2024.115604