In This Issue of Diabetes Care.

The article focuses on the analysis of the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE) by Garvey et al., revealing baseline factors associated with glycemic outcomes. It reports that younger age and baseline Glycated hemoglobin (HbA1c) increased the risk of reaching glycemic outcomes, with treatment group associations. It highlights for more aggressive treatment and follow-up, especially in patients with younger onset and high HbA1c values.