骨组织工程中促血管支架应用的可视化分析.

BACKGROUND: The study of the physical properties of scaffolds has always been a hot topic in the field of tissue engineering research. However, for vascular stimulating scaffolds, in addition to meeting the basic performance of the scaffold, other methods are also needed to promote the regeneration of blood vessels within the scaffold, in order to achieve the ultimate goal of repairing bone tissue. OBJECTIVE: A visualization analysis was carried out on the literature published in and outside China on scaffold stimulation for bone tissue engineering, to explore the research hotspots and research status in this field, and to provide a reference for subsequent studies. METHODS: Using the CNKI database and Web of Science core database as retrieval databases, the relevant literature on vascular scaffolds for bone tissue engineering was retrieved. The literature that did not conform to the research object was removed. The obtained data were imported into CiteSpace 6.1.R2 software. Visualization analysis was performed on authors, national institutions, and keywords in the research field. RESULTS AND CONCLUSION: (1) China, the United States, and Germany were the top three countries with the most articles on scaffold stimulation for bone tissue engineering. (2) The top 3 institutions in the CNKI database were Southern Medical University, Huazhong University of Science and Technology, and Donghua University. In the core database of Web of Science, Shanghai Jiao Tong University, Sichuan University and Chinese Academy of Sciences ranked the top 3 in terms of the number of institutional publications. (3) The top 3 keywords in the CNKI database were “tissue engineering, vascularization, angiogenesis”. The top 3 keywords in the Web of Science core database were “mesenchymal stem cell, scaffold, vascularization”. (4) Through the analysis of co-citation and highly cited references, the main concerns were as follows: vascularization strategies: scaffold design, angiogenic factor delivery, in vitro co-culture, and in vivo prevascularization. Technology: 3D printing, electrospinning, vascular transplantation, vascular fusion. Mechanisms: immune regulation and macrophages, drug/ growth factor delivery, the relationship between endothelial cells and osteoblasts, the paracrine relationship between bone cells and endothelial cells, signaling molecular pathways, angiogenesis, and anti-angiogenesis molecules. (5) The researches concerning vascular stimulating scaffolds in bone tissue engineering in and outside China attach great importance to the application of stem cells and 3D printing technology. Current research focuses on biological 3D printing technology, scaffold modification methods, and the development and application of intelligent biomaterials based on bone repair mechanisms. [ABSTRACT FROM AUTHOR]