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Infection frequency may not increase in Familial Mediterranean fever.
- Source :
-
Journal of Turkish Society for Rheumatology . 2024, Vol. 16 Issue 1, p15-24. 10p. - Publication Year :
- 2024
-
Abstract
- Objective: To the best of our knowledge, there is no study evaluating the infectious features of Familial Mediterranean fever (FMF) in the literature. Here, we tested two hypotheses: infection is more common in FMF and FMF severity and infection may be linked. Methods: We included three groups: FMF (363 patients), spondyloarthropathy (SpA-patients) (112 patients) and control (121 patients). We screened participants for infection characteristics in the last year with a pre-approved and validated questionnaire. Firstly, we compared infection rates, frequency of infection types, and infection severity within groups. We then evaluated the factors associated with infection in FMF. Results: We found that infection rates were similar in FMF, SpA-patients and controls. However, admission to the infection outpatient clinic was more common in FMF (p=0.001) and the duration of workforce loss due to infection was longer in FMF than controls (p=0.002). Furthermore, FMF-patients with infection had higher disease severity (p=0.004), high acute phase reactants between attacks (p=0.006) and more site involvement during attacks (p<0.001). In multivariate analyses, the latter was found to be significant (p=0.003). Conclusion: We discovered no increase in the infection rate of FMF patients. Patients with infections, on the other hand, may have more severe FMF. [ABSTRACT FROM AUTHOR]
- Subjects :
- *FAMILIAL Mediterranean fever
*QUESTIONNAIRES
*LABOR supply
*INFECTION
*OUTPATIENTS
Subjects
Details
- Language :
- English
- ISSN :
- 26512653
- Volume :
- 16
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Journal of Turkish Society for Rheumatology
- Publication Type :
- Academic Journal
- Accession number :
- 176400708
- Full Text :
- https://doi.org/10.4274/raed.galenos.2024.52714