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Transcriptomic responses of rabbits to infections by precocious line and wild-type Eimeria media: revealing molecular signatures and pathway differences in liver and duodenum during the peak and terminal phases of oocyst production.
- Source :
-
Parasitology Research . Apr2024, Vol. 123 Issue 4, p1-10. 10p. - Publication Year :
- 2024
-
Abstract
- Eimeria media is a principal pathogen responsible for rabbit coccidiosis, targeting the rabbit’s intestinal epithelial cells. This parasitism damages the intestinal mucosal barrier, initiating a systemic immune and inflammatory response that jeopardizes the sustainable growth of rabbit farming. To understand the implications of infection on the host’s immune and metabolic responses, we employed RNA-Seq to analyze RNA from the liver and duodenum tissues of post-infected rabbits infected with both the precocious line and wild-type strain of E.media. Comprehensive transcriptomic analysis revealed that the two parasites exhibit divergent transcriptomic imprints on host tissues. While the precocious line predominantly modulates immune-centric pathways with significant differential gene enrichment, wild-type strain favors pathways that affect metabolism. In addition, our study pinpointed a set of genes that undergo significant modifications in response to these effects. These revelations grant a fresh avenue to probe deeper into the symbiotic intricacies of the E.media and its rabbit host. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09320113
- Volume :
- 123
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Parasitology Research
- Publication Type :
- Academic Journal
- Accession number :
- 176423775
- Full Text :
- https://doi.org/10.1007/s00436-024-08186-1