Editorial on polygenic risk scores: Colloquium held at the Centre for Personalised Medicine, Oxford.

Polygenic risk scores (PRSs) are being explored in personalized medicine as a way to understand an individual's susceptibility to diseases. These scores combine the effects of multiple genetic variants to assess the risk of common diseases like heart disease and cancer. Incorporating PRSs into risk assessment tools can improve predictions and inform population health strategies. However, there are challenges to consider, such as the limited predictive ability of PRSs and the need for evidence-based interventions. The use of PRSs also raises ethical concerns, including labeling children with health risks and widening health inequalities. Further research and discussions are necessary to address these complex issues. The document provides a list of scientific articles on the topic, covering various aspects of using PRSs in precision medicine. These articles highlight the potential benefits and challenges of PRSs in healthcare, emphasizing the importance of diverse representation and realistic expectations. [Extracted from the article]