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Discriminative potential of exhaled breath condensate biomarkers with respect to chronic obstructive pulmonary disease.
- Source :
-
Journal of Occupational Medicine & Toxicology . 4/4/2024, Vol. 19 Issue 1, p1-10. 10p. - Publication Year :
- 2024
-
Abstract
- Background: Chronic obstructive pulmonary disease (COPD) affecting 334 million people in the world remains a major cause of morbidity and mortality. Proper diagnosis of COPD is still a challenge and largely solely based on spirometric criteria. We aimed to investigate the potential of nitrosative/oxidative stress and related metabolic biomarkers in exhaled breath condensate (EBC) to discriminate COPD patients. Methods: Three hundred three participants were randomly selected from a 15,000-transit worker cohort within the Respiratory disease Occupational Biomonitoring Collaborative Project (ROBoCoP). COPD was defined using the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria as post-bronchodilator ratio of Forced Expiratory Volume in 1st second to Forced Vital Capacity < 0.7 in spirometry validated by an experienced pulmonologist. Discriminative power of biomarker profiles in EBC was analyzed using linear discriminant analyses. Results: Amongst 300 participants with validated spirometry, 50.3% were female, 52.3 years old in average, 36.0% were current smokers, 12.7% ex-smokers with mean tobacco exposure of 15.4 pack-years. Twenty-one participants (7.0%) were diagnosed as COPD, including 19 new diagnoses, 12 of which with a mild COPD stage (GOLD 1). Amongst 8 biomarkers measured in EBC, combination of 2 biomarkers, Lactate and Malondialdehyde (MDA) significantly discriminated COPD subjects from non-COPD, with a 71%-accuracy, area under the receiver curve of 0.78 (p-value < 0.001), and a negative predictive value of 96%. Conclusions: These findings support the potential of biomarkers in EBC, in particular lactate and MDA, to discriminate COPD patients even at a mild or moderate stage. These EBC biomarkers present a non-invasive and drugless technique, which can improve COPD diagnosis in the future. [ABSTRACT FROM AUTHOR]
- Subjects :
- *OBSTRUCTIVE lung disease diagnosis
*PREDICTIVE tests
*SPIROMETRY
*ENVIRONMENTAL monitoring
*VITAL capacity (Respiration)
*RESPIRATION
*STATISTICAL sampling
*OXIDATIVE stress
*DESCRIPTIVE statistics
*LONGITUDINAL method
*DISEASES
*OBSTRUCTIVE lung diseases
*FORCED expiratory volume
*BREATH tests
*BIOMARKERS
*DISCRIMINANT analysis
*BRONCHODILATOR agents
*MALONDIALDEHYDE
Subjects
Details
- Language :
- English
- ISSN :
- 17456673
- Volume :
- 19
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Journal of Occupational Medicine & Toxicology
- Publication Type :
- Academic Journal
- Accession number :
- 176465254
- Full Text :
- https://doi.org/10.1186/s12995-024-00409-6