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Enhanced antibacterial activity of bovine milk exosome-based drug formulation against bacterial pathogens.
- Source :
-
Food Chemistry . Jul2024, Vol. 447, pN.PAG-N.PAG. 1p. - Publication Year :
- 2024
-
Abstract
- • Milk exosomes was used to co-delivery of isobavachalcone and polymyxin. • Isobavachalcone and polymyxin exhibit good synergistic antimicrobial effects. • Milk exosomes improve the solubility and efficacy of isobavachalcone. Milk is not only a source of nutrients, but also contains exosomes (Exo) that can serve as a vehicle for drug delivery. Here, we obtained bovine milk Exo using three efficient methods, demonstrating high quality for commercial production. The optimized Exo displayed a size of 105.2 nm and an entrapment efficiency of 88.4 %. The Exo has been functionalized with a combination therapy comprising isobavachalcone (IS) and polymyxin B (PB), referred to as IP-Exo. The antibacterial efficacy of IP-Exo was significantly enhanced, enabling the elimination of 99 % of multidrug-resistant (MDR) bacterial pathogens in 4 h. Furthermore, scanning electron microscopy images demonstrated that the drug combination led to the complete dismantling of the bacterial structure. IP-Exo showed nearly 100 % microbial inhibition in fresh orange juice and accelerated wound healing in mouse models. Collectively, IP-Exo provides excellent potential for application within the food industry and animal husbandry as a defense against bacterial pathogens. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03088146
- Volume :
- 447
- Database :
- Academic Search Index
- Journal :
- Food Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 176470364
- Full Text :
- https://doi.org/10.1016/j.foodchem.2024.139034