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Practical gram-scale synthesis of bicyclol metabolites M2 and M3.
- Source :
-
Journal of Asian Natural Products Research . Mar2024, Vol. 26 Issue 3, p342-352. 11p. - Publication Year :
- 2024
-
Abstract
- Bicyclol, an innovative hepatoprotective drug, was approved by the Chinese National Medical Products Administration (NMPA) in 2001 to treat Hepatitis B and drug-induced liver injury. Two active metabolites of bicyclol have been identified as M2 and M3. To evaluate the impact on drug safety and efficacy of possible drug-drug interactions (DDIs) associated with these metabolites, a sufficient quantity of these metabolites is required. Herein, we report a concise novel route for the synthesis of M2 and M3 using the Suzuki-Miyaura coupling as the key step. Furthermore, we complete the gram-scale syntheses of M2 and M3. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10286020
- Volume :
- 26
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Journal of Asian Natural Products Research
- Publication Type :
- Academic Journal
- Accession number :
- 176494960
- Full Text :
- https://doi.org/10.1080/10286020.2023.2270440