Synthesis of Amides and Peptides by Employing [4-(Acetylamino) phenyl]imidodisulfuryl Difluoride (AISF) as a Coupling Reagent.

This article discusses the synthesis of amides and peptides using a new acid activator called [4-(acetylamino)phenyl]imidodisulfuryl difluoride (AISF). The authors optimized the reaction conditions and found that the method was suitable for various carboxylic acids, amines, and amino acids. The protocol was demonstrated to be racemization-free and suitable for gram-scale reactions. The article also provides detailed information about the chemical properties and characterization of various compounds, including their yields, physical properties, and spectroscopic data. The supporting information for the article is available online. [Extracted from the article]