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Radical Mediated Decarboxylation of Amino Acids via Photochemical Carbonyl Sulfide (COS) Elimination.
- Source :
-
Molecules . Apr2024, Vol. 29 Issue 7, p1465. 12p. - Publication Year :
- 2024
-
Abstract
- Herein, we present the first examples of amino acid decarboxylation via photochemically activated carbonyl sulfide (COS) elimination of the corresponding thioacids. This method offers a mild approach for the decarboxylation of amino acids, furnishing N-alkyl amino derivatives. The methodology was compatible with amino acids displaying both polar and hydrophobic sidechains and was tolerant towards widely used amino acid-protecting groups. The compatibility of the reaction with continuous-flow conditions demonstrates the scalability of the process. [ABSTRACT FROM AUTHOR]
- Subjects :
- *DECARBOXYLATION
*AMINO group
*SULFIDES
*AMINO acids
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 29
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Molecules
- Publication Type :
- Academic Journal
- Accession number :
- 176597516
- Full Text :
- https://doi.org/10.3390/molecules29071465