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Chitosan nanoparticles as a novel delivery system for ammonium glycyrrhizinate
- Source :
-
International Journal of Pharmaceutics . May2005, Vol. 295 Issue 1/2, p235-245. 11p. - Publication Year :
- 2005
-
Abstract
- Abstract: The ammonium glycyrrhizinate-loaded chitosan nanoparticles were prepared by ionic gelation of chitosan with tripolyphosphate anions (TPP). The particle size and zeta potential of nanoparticles were determined, respectively, by dynamic light scattering (DLS) and a zeta potential analyzer. The effects, including chitosan molecular weight, chitosan concentration, ammonium glycyrrhizinate concentration and polyethylene glycol (PEG) on the physicochemical properties of the nanoparticles were studied. These nanoparticles have ammonium glycyrrhizinate loading efficiency. The encapsulation efficiency decreased with the increase of ammonium glycyrrhizinate concentration and chitosan concentration. The introduction of PEG can decrease significantly the positive charge of particle surface. These studies showed that chitosan can complex TPP to form stable cationic nanoparticles for subsequent ammonium glycyrrhizinate loading. [Copyright &y& Elsevier]
- Subjects :
- *NANOPARTICLES
*LIGHT scattering
*MOLECULAR weights
*POLYETHYLENE glycol
Subjects
Details
- Language :
- English
- ISSN :
- 03785173
- Volume :
- 295
- Issue :
- 1/2
- Database :
- Academic Search Index
- Journal :
- International Journal of Pharmaceutics
- Publication Type :
- Academic Journal
- Accession number :
- 17674330
- Full Text :
- https://doi.org/10.1016/j.ijpharm.2005.01.042