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Synthesis, Antioxidant and Antimicrobial Activity of Calix[4]Arene Acetanilide Derivative.

Authors :
Qureshi, Muhammad Murtaza
Junejo, Ranjhan
Memon, Fakhar N.
Memon, Shahabuddin
Khuhawar, Muhammad Yar
Source :
Polycyclic Aromatic Compounds. 2024, Vol. 44 Issue 3, p2119-2127. 9p.
Publication Year :
2024

Abstract

The current work explores the antioxidant and antimicrobial activity of a newly synthesized calix[4] arene acetanilide derivative (3), which was synthesized through Mannich reaction by the treatment of calix[4] arene with acetanilide, formaldehyde and acetic acid in tetrahydrofuran, The antioxidant activity was determined by using DPPH method. Results show that the new synthesized compound 3 has good antioxidant activity. The antimicrobial activity of 3 was staunched against different types of microorganisms, i.e. gram-negative and gram-positive bacterial strains (Escherichia Coli ATCC 8739 and Staphylococcus Aureus ATCC 10231) along with a fungus (Aspergillus Niger ATCC 16405). A suitable agar medium (Mueller Hinton agar) was applied for the growth of microorganisms. Kirby-Bauer well agar diffusion method was used to check the antimicrobial activity. The bacterial strains zone has been observed in between 250–4000 µg/ml. It is noticed that compound 3 has very good effect against fungus A niger as compared to bacterial strains. Its minimum inhibitory concentration (MIC) against A. niger, S. aureus and E. coli is found to be 250, 500 and 1000 µg/mL, respectively. Consequently, the study has been compared with the reported calix[4] arene derivatives and it has been revealed that the compound 3 is a good antimicrobial agent. Hence, it could be inferred that compound 3 is considerably effective against selected microorganisms and may be used as a medicine in near future and beneficial for the human. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
10406638
Volume :
44
Issue :
3
Database :
Academic Search Index
Journal :
Polycyclic Aromatic Compounds
Publication Type :
Academic Journal
Accession number :
176763437
Full Text :
https://doi.org/10.1080/10406638.2023.2212106