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Cyclopropylmethylidene as a versatile protecting group for carbohydrate synthesis.
- Source :
-
Journal of Carbohydrate Chemistry . 2023, Vol. 42 Issue 7-9, p294-308. 15p. - Publication Year :
- 2023
-
Abstract
- Cyclopropylmethylidene has been developed as a versatile protecting group for carbohydrate synthesis. It can be formed by acid-catalyzed acetalization between cyclopropanecarboxaldehyde and 1,3-diols of sugar molecules. Selective reductive opening of the 4,6-O-cyclopropylmethylidene can be achieved to afford a C4 free hydroxyl group and a C6-cyclopropylmethyl (CPM) ether or vice versa. The cyclopropylmethylidene was found to be less stable than benzylidene under acidic conditions. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CARBOHYDRATES
*FREE groups
*HYDROXYL group
*AMINATION
Subjects
Details
- Language :
- English
- ISSN :
- 07328303
- Volume :
- 42
- Issue :
- 7-9
- Database :
- Academic Search Index
- Journal :
- Journal of Carbohydrate Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 176763457
- Full Text :
- https://doi.org/10.1080/07328303.2024.2332282