Nickel Nanocluster as a Fluorescent Probe for the Non-enzymatic Detection of Cardiac Troponin I.

Troponin I, as a cardiac-specific biomarker, is a very valuable tool in the identification of acute coronary syndromes. In this work, an economical technique for easy and sensitive diagnosis of cardiac troponin I (cTnI) was developed nanoprobe on the basis of graphene oxide quenching of the fluorescence of bovine serum albumin–capped fluorescent nickel (BSA@NiNCs) nanoclusters. The developed nanoprobe nickel nanocluster exhibited superparamagnetism. The nanoprobe showed a fluorescence turn-on behavior toward incremental addition of in cTnI, with a detection limit of 0.012 ng/mL. We successfully used the proposed sensing technique for cTnI sensing in serum samples. [ABSTRACT FROM AUTHOR]