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Psilocybin therapy and anorexia nervosa: a narrative review of safety considerations for researchers and clinicians.

Authors :
Downey, Amanda E.
Chaphekar, Anita V.
Woolley, Joshua
Raymond-Flesch, Marissa
Source :
Journal of Eating Disorders. 4/24/2024, Vol. 12 Issue 1, p1-9. 9p.
Publication Year :
2024

Abstract

Background: Clinical trials using psilocybin therapy to treat anorexia nervosa (AN) are currently underway. The safety and tolerability of psilocybin is of utmost importance in individuals with AN who may present unique medical vulnerabilities. The purpose of this review is to describe how the common physiologic adverse effects of psilocybin may impact medical complications experienced by individuals with AN in clinical trials of psilocybin therapy. Main body: The physiologic underpinnings of common adverse effects following psilocybin administration are described, including tachycardia, hypertension, electrocardiogram changes, nausea, headache, and lightheadedness. These anticipated physiologic changes are described in relation to the common medical correlates seen in individuals with AN. Risk mitigation strategies for each adverse effect are proposed. Conclusion: Early evidence suggests that psilocybin therapy is well-tolerated in individuals with AN. Understanding the unique medical complications of AN, and how they may be impacted by common physiologic adverse effects of psilocybin administration, leads to tailored risk mitigation strategies to enhance safety and tolerability of this novel intervention. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20502974
Volume :
12
Issue :
1
Database :
Academic Search Index
Journal :
Journal of Eating Disorders
Publication Type :
Academic Journal
Accession number :
176842452
Full Text :
https://doi.org/10.1186/s40337-024-01005-z