Back to Search Start Over

Reproductive toxicity of cadmium stress in male animals.

Authors :
Zhang, Zikun
Wang, Qi
Gao, Xiaoge
Tang, Xu
Xu, Huan
Wang, Wenqiang
Lei, Xin
Source :
Toxicology. May2024, Vol. 504, pN.PAG-N.PAG. 1p.
Publication Year :
2024

Abstract

Cadmium (Cd) is a common heavy metal pollutant in the environment, and the widespread use of products containing Cd compounds in industry has led to excessive levels in the environment, which enter the animal body through the food chain, thus seriously affecting the reproductive development of animals. Related studies have reported that Cd severely affects spermatogonia development and spermatogenesis in animals. In contrast, the reproductive toxicity of Cd in males and its mechanism of action have not been clarified. Therefore, this paper reviewed the toxic effects of Cd on germ cells, spermatogonia somatic cells and hypothalamic-pituitary-gonadal axis (HPG axis) of male animals and its toxic action mechanisms of oxidative stress, apoptosis and autophagy from the perspectives of cytology, genetics and neuroendocrinology. The effects of Cd stress on epigenetic modification of reproductive development in male animals were also analyzed. We hope to provide a reference for the in-depth study of the toxicity of Cd on male animal reproduction. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
0300483X
Volume :
504
Database :
Academic Search Index
Journal :
Toxicology
Publication Type :
Academic Journal
Accession number :
176864534
Full Text :
https://doi.org/10.1016/j.tox.2024.153787