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Ex vivo therapeutic screening of metastatic cSCC: A review of methodological considerations for clinical implementation.
- Source :
-
Experimental Dermatology . Apr2024, Vol. 33 Issue 4, p1-12. 12p. - Publication Year :
- 2024
-
Abstract
- Cutaneous squamous cell carcinoma (cSCC) is the second most common malignancy worldwide, with most deaths caused by locally advanced and metastatic disease. Treatment of resectable metastases is typically limited to invasive surgery with adjuvant radiotherapy; however, many patients fail to respond and there is minimal data to predict response or propose effective alternatives. Precision medicine could improve this, though genomic biomarkers remain elusive in the high mutational background and genomic complexity of cSCC. A phenotypic approach to precision medicine using patientāderived ex vivo tumour models is gaining favour for its capacity to directly assess biological responses to therapeutics as a functional, predictive biomarker. However, the use of ex vivo models for guiding therapeutic selection has yet to be employed for metastatic cSCC. This review will therefore evaluate the existing experimental models of metastatic cSCC and discuss how ex vivo methods could overcome the shortcomings of these existing models. Diseaseāspecific considerations for a prospective methodological pipeline will also be discussed in the context of precision medicine. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MEDICAL screening
*SQUAMOUS cell carcinoma
*METASTASIS
*INDIVIDUALIZED medicine
Subjects
Details
- Language :
- English
- ISSN :
- 09066705
- Volume :
- 33
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Experimental Dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 176867588
- Full Text :
- https://doi.org/10.1111/exd.15089