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Application of Biomarkers in Obese Infertile Women: A Genetic Tool for a Personalized Treatment.

Authors :
Voros, Charalampos
Bananis, Kyriakos
Papapanagiotou, Angeliki
Pouliakis, Abraham
Mavriki, Konstantina
Gkaniatsos, Ioannis
Daskalaki, Maria Anastasia
Prokopakis, Ioannis
Tsimpoukelis, Charalampos
Koulakmanidis, Aristotelis-Marios
Darlas, Menelaos
Anysiadou, Sofia
Daskalakis, Georgios
Domali, Ekaterini
Source :
Journal of Clinical Medicine. Apr2024, Vol. 13 Issue 8, p2261. 12p.
Publication Year :
2024

Abstract

This study investigates links between CART and leptin gene expression, FSH receptor Asn680Ser polymorphism, and reproductive hormones in morbidly obese patients under 40 years old, facing infertility, and undergoing bariatric surgery. A total of 29 women were included in this study. A hormonal profile along with detection of CART and leptin gene expression was evaluated before and after bariatric surgery. Additionally, the presence or absence of Asn680Ser of the FSHR gene was studied. Following bariatric surgery, a mean reduction in BMI (16.03 kg/m2) was observed in all women. FSH levels preoperatively varied significantly among genotypes, with medians of 8.1, 9.5, and 10.3 for individuals without polymorphism, heterozygotes, and homozygotes, respectively (p = 0.0408). Post surgery, marginal differences in FSH levels were observed (5.8, 7.1, and 8.2, respectively) (p = 0.0356). E2 and LH levels exhibited no significant genotype-based differences pre and post surgery. Presurgical E2 levels were 29.6, 29.8, and 29.6, respectively (p = 0.91634), while postsurgical levels were 51.2, 47.8, and 47 (p = 0.7720). LH levels followed similar patterns. Our findings highlight bariatric surgery's positive impact on BMI reduction and its potential connection to genetic markers, hormones, and infertility. This suggests personalized treatments and offers a valuable genetic tool for better fertility outcomes in obese individuals. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20770383
Volume :
13
Issue :
8
Database :
Academic Search Index
Journal :
Journal of Clinical Medicine
Publication Type :
Academic Journal
Accession number :
176876309
Full Text :
https://doi.org/10.3390/jcm13082261