Organic photoelectrochemical transistor based on cascaded DNA network structure modulated ZnIn2S4/MXene Schottky junction for sensitive ATP detection.

Organic photoelectrochemical transistor (OPECT) biosensor is now appearing in perspective of public, which characterized by amplified the grating electrode potential by ion transport. In this study, the DNA network formed by the hybridization chain reaction (HCR) detects the target adenosine triphosphate (ATP) by adjusting the surface potential of the new heterojunction of ZnIn 2 S 4 /MXene. The formation of DNA network amplifies the detection signal of ATP. Significantly, OPECT biosensor could further amplify the signal, which calculated the gain achieved 103, which is consistent with the gain signal of the previously reported OPECT biosensor. Furthermore, the OPECT biosensor achieved a highly sensitivity detection of the target ATP, which the linear detection range is 0.03 pM–30 nM, and the detection limit is 0.03 pM, and illustrated a high selectivity to ATP. The proposed OPECT biosensor achieved signal amplification by adjusting the surface potential of ZnIn 2 S 4 /MXene through cascade DNA network, which provides a new direction for the detection of biomolecules. We designed an ultrasensitive method for organic photoelectrochemical transistor detection of ATP based on DNA network structure modulated ZnIn 2 S 4 /MXene schottky junction. [Display omitted] • A new Schottky junction of MXene/ZnIn 2 S 4 is applied to organic phototransistors. • An enzyme-free labelled DNA-assisted isothermal amplification system was designed. • The detection of ATP with organic photoelectrochemical transistor was realized. [ABSTRACT FROM AUTHOR]