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Fecal Calprotectin in Patients with Crohn's Disease: A Study Based on the History of Bowel Resection and Location of Disease.

Authors :
Seo, Jeongkuk
Song, Subin
Shin, Seung Hwan
Park, Suhyun
Hong, Seung Wook
Park, Sang Hyoung
Yang, Dong-Hoon
Ye, Byong Duk
Byeon, Jeong-Sik
Myung, Seung-Jae
Yang, Suk-Kyun
Hwang, Sung Wook
Source :
Diagnostics (2075-4418). Apr2024, Vol. 14 Issue 8, p854. 12p.
Publication Year :
2024

Abstract

Fecal calprotectin (FC) is commonly used to assess Crohn's disease (CD) activity. However, standardized cut-off values accounting for bowel resection history and disease location are lacking. In this study, we analyzed data from patients with CD who underwent magnetic resonance enterography, ileocolonoscopy, and FC measurements from January 2017 to December 2018. In 267 cases from 254 patients, the FC levels in the 'operated' patients were higher when the disease was active compared with those who were in the remission group (178 vs. 54.7 μg/g; p < 0.001), and similar findings were obtained for the 'non-operated' patients (449.5 vs. 40.95 μg/g; p < 0.001). The FC levels differed significantly according to the location of inflammation, with lower levels in the small bowel compared to those in the colon. The FC cut-off levels of 70.8 μg/g and 142.0 μg/g were considered optimal for predicting active disease for operated and non-operated patients, respectively. The corresponding FC cut-off levels of 70.8 μg/g and 65.0 μg/g were observed for patients with disease only in the small bowel. In conclusion, different FC cut-off values would be applicable to patients with CD based on their bowel resection history and disease location. Tight control with a lower FC target may benefit those with a history of bowel resection or small-bowel-only disease. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20754418
Volume :
14
Issue :
8
Database :
Academic Search Index
Journal :
Diagnostics (2075-4418)
Publication Type :
Academic Journal
Accession number :
176906922
Full Text :
https://doi.org/10.3390/diagnostics14080854