VMAT structures reveal exciting targets for drug development.

Vesicular monoamine transporter (VMAT)-2 has a crucial role in the neurotransmission of biogenic amines. Recently, Dalton et al. , Pidathala et al. , Wu et al. , and Wang et al. individually reported cryo-electron microscopy (EM) structures of human VMAT2, offering opportunities for developing improved therapeutics and deep insights into the functioning of this protein. [ABSTRACT FROM AUTHOR]